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Index > Protein center > CDNF(Gene name) > Human
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  • CDNF (Gene name),
  • Cerebral dopamine neurotrophic factor (Protein name ),  CDNF_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CDNF(ARMETL1);
    Protein name:
    Cerebral dopamine neurotrophic factor;
    Alternative:
    Conserved dopamine neurotrophic factor;ARMET-like protein 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    187
    Sequence:
    50:
    MWCASPVAVV | AFCAGLLVSH | PVLTQGQEAG | GRPGADCEVC | KEFLNRFYKS | 
    100:
    LIDRGVNFSL | DTIEKELISF | CLDTKGKENR | LCYYLGATKD | AATKILSEVT | 
    150:
    RPMSVHMPAM | KICEKLKKLD | SQICELKYEK | TLDLASVDLR | KMRVAELKQI | 
    187:
    LHSWGEECRA | CAEKTDYVNL | IQELAPKYAA | THPKTEL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    MIM:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cerebral dopamine neurotrophic factor
    Cat.:
    E12632h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Cerebral dopamine neurotrophic factor
    Cat.:
    E12632r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Cerebral dopamine neurotrophic factor
    Cat.:
    E12632m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Cerebral dopamine neurotrophic factor
    Cat.:
    U12632h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Cerebral dopamine neurotrophic factor
    Cat.:
    U12632m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Cerebral dopamine neurotrophic factor
    Cat.:
    U12632r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Cerebral dopamine neurotrophic factor
    Cat.:
    P12632Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cerebral dopamine neurotrophic factor
    Cat.:
    P12632Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cerebral dopamine neurotrophic factor
    Cat.:
    P12632Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Cerebral dopamine neurotrophic factor
    Monoclonal Antibody for Human Cerebral dopamine neurotrophic factor
    Monoclonal Antibody for Human Cerebral dopamine neurotrophic factor
    Protein for Human Cerebral dopamine neurotrophic factor
    Protein for Human Cerebral dopamine neurotrophic factor
    Protein for Human Cerebral dopamine neurotrophic factor

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    Linearity
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    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Spleen.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Testis.
    4. 4.
      "Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo."
      Lindholm P. , Voutilainen M.H. , Lauren J. , Peraenen J. , Leppaenen V.-M. , Andressoo J.-O. , Lindahl M. , Janhunen S. , Kalkkinen N. , Timmusk T. , Tuominen R.K. , Saarma M.
      Nature448:73-77(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    5. 5.
      "Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death."
      Apostolou A. , Shen Y. , Liang Y. , Luo J. , Fang S.
      Exp. Cell Res.314:2454-2467(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INDUCTION
    6. 6.
      "The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional."
      Parkash V. , Lindholm P. , Peranen J. , Kalkkinen N. , Oksanen E. , Saarma M. , Leppanen V.-M. , Goldman A.
      Protein Eng. Des. Sel.22:233-241(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 32-133;DISULFIDE BONDS
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